Wissenschaftliche Publikationen (2005 - 2008)
Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten  


Schulz C, Konrad I, Sauer S, Orschiedt L, Koellnberger M, Lorenz R, Walter U, Massberg S. (2008) Effect of chronic treatment with acetylsalicylic acid and clopidogrel on atheroprogression and atherothrombosis in ApoE-deficient mice in vivo. Thomb Haemost. 99(1):190-5.

Gimona M, Buccione R, Courtneidge S, Linder S. (2008) Assembly and biological role of podosomes and invadopodia. Current Opinion in Cell Biology 20(2):235-41.

Thal DR, Xavier CP, Rosentreter A, Linder S, Friedrichs B, Waha A, Pietsch T, Stumpf M, Noegel AA, Clemen CS. (2008) Expression of coronin-3 (coronin-IC) in diffuse gliomas is related to malignancy. J Pathol. 214(4):415-24.

Rode S, Rubic T, Lorenz RL. (2008) alpha-Tocopherol disturbs macrophage LXRalpha regulation of ABCA1/G1 and cholesterol handling. Biochem Biophys Res Commun. 369(3):868-72.

Krump-Konvalinkova V, Chwalla I, Siess W. (2008) FTY720 inhibits S1P-mediated endothelial healing: Relationship to S1P1-receptor surface expression. Biochem Biophys Res Commun. 370(4):603-08.

Reichel CA, Rehberg M, Bihari P, Moser CM, Linder S, Khandoga A, Krombach F. (2008) Gelatinases mediate neutrophil recruitment in vivo: evidence for stimulus specificity and a critical role in collagen IV remodeling. J Leukoc Biol. 83(4):864-74.

Schulz C, Penz S, Hoffmann C, Langer H, Gillitzer A, Schneider S, Brandl R, Seidl S, Massberg S, Pichler B, Kremmer E, Stellos K, Schönberger T, Siess W, Gawaz M. (2008) Platelet GPVI binds to collagenous structures in the core region of human atheromatous plaque and is critical for atheroprogression in vivo. Basic Res Cardiol. 103(4):356-67.

Weinmeister P, Lukowski R, Linder S, Traidl-Hoffmann C, Hengst L, Hofmann F, Feil R. (2008) Cyclic guanosine monophosphate-dependent protein kinase I promotes adhesion of primary vascular smooth muscle cells. Mol Biol Cell 19(10):4434-41.

Khandoga AL, Fujiwara Y, Goyal P, Pandey D, Tsukahara,R., Bolen,A., Guo, F., Wilke N, Liu J, Valentine WJ, Durgam GG, Miller DD, Jiang G, Prestwich GD, Tigyi G, and Siess W. (2008) Lysophosphatidic acid-induced platelet shape change revealed through LPA1-5 receptor-selective probes and albumin. Platelets 19(6):415-27.

Buccione R, Gimona M, Linder S. (2008) FEBS workshop: invadopodia podosomes and focal adhesions in tissue invasion. Eur J Cell Biol. 87(8-9):457-8.


Penz SM, Reininger AJ, Toth O, Deckmyn H, Brandl R, Siess W (2007) Glycoprotein Ibalpha inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques. Thromb Haemost. 97(3):435-43.

Tyagi NK, Kumar A, Goyal P, Pandey D, Siess W, Kinne RK (2007) D-Glucose-recognition and phlorizin-binding sites in human sodium/D-glucose cotransporter 1 (hSGLT1): a tryptophan scanning study. Biochemistry 46(47):13616-28.

Kumar A, Tyagi NK, Goyal P, Pandey D, Siess W, Kinne RK. (2007) Sodium-independent low-affinity D-glucose transport by human sodium/D-glucose cotransporter 1: critical role of tryptophan 561. Biochemistry 46(10):2758-66.

Pandey D, Goyal P, Siess W. (2007) Lysophosphatidic acid stimulation of platelets rapidly induces Ca2+-dependent dephosphorylation of cofilin that is independent of dense granule secretion and aggregation. Blood Cell Mol Dis. 38(3):269-79.

Erl W. (2007) Atorvastatin-inducd downregulation of survivin and vascular smooth muscle cell apoptosis: a causal relationship in restenosis? Cardiovasc Drug Ther. 21:141-144.

Linder, S. (2007) The matrix corroded: podosomes and invadopodia in extracellular matrix degradation. Trends in Cell Biology 17(3):1107-117.

Trasak C, Zenner G, Vogel A, Yüksekdag G, Rost R, Haase I, Fischer M, Israel L, Imhof A, Linder S, Schleicher M, Aepfelbacher M. (2007) Yersinia protein kinase YopO is activated by a novel G-actin binding process. J Biol Chem. 282(4):2268-2277.

Chellaiah, MA, Kappuswamy D, Lasky L, Linder S. (2007) Phosphorylation of a Wiscott-Aldrich syndrome protein-associated signal complex is critical in osteoclast bone resorption. J Biol Chem. 282(13):10104-10116.

Newill H, Loske R, Wagner J, Johannes C, Lorenz RL, Lehmann L. (2007) Oxidation products of stigmasterol interfere with the action of the female sex hormone 17beta-estradiol in cultured human breast and endometrium cell lines. Mol Nutr Food Res. 51:888-98.

Schulz C, Konrad I, Sauer S, Orschiedt L, Koellnberger M, Lorenz R, Walter U, Massberg S. (2007) Effect of chronic treatment with acetylsalicylic acid and clopidogrelon atheroprogression and atherothrombosis in ApoE-deficient mice in vivo. Thomb Haemost; epub ahead.


Pfrommer CA, Erl W, Weber PC. Docosahexaenoic acid induces ciap1 mRNA and protects human endothelial cells from stress-induced apoptosis. (2006) Am J Physiol Heart Circ Physiol. 290(6):H2178-86.

Pandey D, Goyal P, Bamburg JR, Siess W. (2006) Regulation of LIM-kinase 1 and cofilin in thrombin-stimulated platelets. Blood 107(2):575-83.

Rubic T, Lorenz RL. (2006) Downregulated CD36 and oxLDL uptake and stimulated ABCA1/G1 and cholesterol efflux as anti-atherosclerotic mechanisms of interleukin-10. Cardiovasc Res. 69(2):527-35.

Kopp P, Lammers R, Aepfelbacher M, Woehlke G, Rudel T, Machuy N, Steffen W, Linder S. (2006) The kinesin KIF1C and microtubule plus ends regulate podosome dynamics in macrophages. Mol Biol Cell 17(6):2811-23.

Gringel A, Walz D, Rosenberger G, Minden A, Kutsche K, Kopp P, Linder S. (2006) PAK4 and aPIX determine podosome size and number in macrophages through localized actin regulation. J Cell Physiol. 209(2):568-579.

Ussar S, Wang H-V, Linder S, Fässler R, Moser M. (2006) The kindlins: subcellular localization and expression during murine development. Exp Cell Res. 312(16):3142-3151.

Weber GF, Gaertner FC, Erl W, Janssen K-P, Blechert B, Holzmann B, Weighardt H, Essler M. (2006) IL-22 mediated tumor growth reduction correlates with inhibition of ERK1/2 and AKT phosphorylation and induction of cell cycle arrest in the G2/M phase. J Immunol. 177(11):8266-8272.

Goyal P, Pandey D, Siess W. (2006) Phosphorylation-dependent regulation of unique nuclear and nucleolar localization signals of LIM kinase 2 in endothelial cells. J Biol Chem. 281(35):25223-25230.

Massberg S, Konrad I, Schürzinger K, Lorenz M, Schneider S, Zohlnhoefer D, Hoppe K, Schiemann M, Kennerknecht E, Sauer S, Schulz C, ,Kerstan S, Rudelius M, Seidl S, Sorge F, Langer H, Peluso M, Goyal P, Vestweber D, Emambokus NR, Busch DH, Frampton J, Gawaz M. (2006) Platelets secrete stromal cell-derived factor 1a and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo. J Exp Med. 203(5):1221-1233.

Siess W. (2006) Platelet interaciton with bioactive lipids formed by mild oxidation of low-density lipoprotein. Pathophysiol Haemost Thromb. 35(3-4):292-304.

Schröder A, Schröder B, Roppenser B, Linder S, Sinha B, Fässler R, Aepfelbacher M. (2006) Staphylococcus aureus fibronectin binding protein-A induces motile attachment sites and complex actin remodeling in living endothelial cells. Mol Biol Cell 17(12):5198-5210.

Linder S. (2006) Sticking to adhesion: A conference focusing on cell-matrix contacts. Eur J Cell Biol. 85(3-4):143.

Daub K, Langer H, Seizer P, Stellos K, May AE, Goyal P, Bigalke B, Schönberger T, Geisler T, Siegel-Axel D, Oostendorp RAJ, Lindemann S, Gawaz M. (2006) Platelets induce differentiation of human CD34+ progenitor cells into foam cells and endothelial cells. FASEB J. 20(14):2559-2561.

Tóth O, Calatzis A, Penz S, Losonczy H. Siess W. (2006) Multiple electrode aggregometry: A new device to measure platelet aggregation in whole blood. Thromb Haemost. 96(6):781-788.


Krump-Konvalinkova V, Yasuda S, Rubic T, Makarova N, Mages J, Erl W, Vosseler C, Kirkpatrick CJ, Tigyi G, Siess W. (2005) Stable knock-down of the sphingosine 1-phosphate receptor S1P1 influences multiple functions of human endothelial cells. Arterioscler. Thromb. Vasc. Biol. 25:546-552.

Kim HJ, Vosseler CA, Weber PC, Erl W. (2005) Docosahexaenoic acid induces apoptosis in proliferating human endothelial cells. J. Cell. Physiol. 204:881-888.

Bu D, Erl W, de Martin R, Hansson GK, Yan Z. (2005) IKKß-dependent NfkB pathway controls vascular inflammation and intimal hyperplasia. FASEB J. 19(10):1293-5.

Osiak A-E, Zenner G, Linder S. (2005) Subconfluent endothelial cells form podosomes downstream of cytokine and RhoGTPase signaling. Exp. Cell Res. 307: 342-353.

Gimona M, Grashoff C, Kopp P. (2005) Oktoberfest for adhesion structures. EMBO Rep. 6:922-926.

Linder S, Kopp P. (2005) Podosomes at a glance. J. Cell. Sci. 118:2079-2082. (IF 6.9)

Göpfert MS, Siedler F, Siess W, Sellmayer A. (2005) Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation. J. Vasc. Res. 42:120-132.

Linder S. (2005) Understanding cell-matrix contacts with the help of nucleofection. Amaxa Newsletter 6:11.

Durgam GG, Virag T, Walker MD, Tsukahara R, Yasuda S, Liliom K, van Meeteren LA, Moolenaar WH, Wilke N, Siess W, Tigyi G, Miller DD. (2005) Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARg and inhibitors of autotaxin. J. Med. Chem. 48:4919-30.

Penz S, Reininger AJ, Brandl R, Goyal P, Rabie T, Bernlochner I, Rother E, Goetz C, Engelmann B, Smethurst PA, Ouwehand WH, Farndale R, Nieswandt B, Siess W. (2005) Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI. FASEB J. 19: 898-909.

Goyal P, Pandey D, Behring A, Siess W. (2005) Inhibition of nuclear import of LIMK2 in endothelial cells by protein kinase C-dependent phosphorylation at Ser283. J. Biol. Chem. 280:27569-77.

Erl W. (2005) Statin-induced vascular smooth muscle cell apoptosis: a possible role in the prevention of restenosis? Curr. Drug Targets - Cardiovasc. & Haematol. Disorders 5:135-144.

Tyagi NK, Goyal P, Kumar A, Pandey D, Siess W, Kinne RKH. (2005) High-yield functional expression of human sodium/D-glucose cotransporter 1 in Pichia pastoris and characterization of ligand-induced conformational changes as studied by tryptophan fluorescence. Biochemistry 44(47):15514-15524.